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Description

In the Phase II trial, 73% to 94% of participants reported side effects with retatrutide, especially at the higher doses of 8 mg and 12 mg once weekly

Gastrointestinal conditions may show earlier improvement, often becoming apparent during the first month of treatment

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Practical note on titration: tirzepatide titration schedules described in trial and community sources typically step up from 2.5 mg 5 mg 7.5 mg 10 mg 15 mg every 4 weeks